Clinical observation on acupuncture for diarrhea-predominant irritable bowel syndrome patients in syndrome of liver-stagnation and spleen-deficiency and its impact on Th1/Th2.
- Author:
Xiao-Liang WU
;
Ye-Lin WANG
;
Jian-Hua SUN
;
Yan-Ye SHU
;
Li-Xia PEI
;
Jun-Ling ZHOU
;
Dong CHEN
;
Ji-Wei ZHANG
;
Dao-Wei ZHAN
- Publication Type:Journal Article
- MeSH: Acupuncture Therapy; Adult; Aged; Cytokines; immunology; Female; Humans; Irritable Bowel Syndrome; immunology; physiopathology; therapy; Liver; physiopathology; Male; Middle Aged; Spleen; physiopathology; Th1 Cells; immunology; Th2 Cells; immunology; Young Adult
- From: Chinese Acupuncture & Moxibustion 2013;33(12):1057-1060
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe clinical therapeutic effects of acupuncture for pattern of liver-stagnation and spleen-deficiency in diarrhea-predominant irritable bowel syndrome (D-IBS) and its impact on cell factors.
METHODSForty cases were selected and divided into an acupuncture group (21 cases) in which acupuncture was applied and a medicine group (19 cases) in which oral administration of dicetel and bifidobacterium lactobacillus triple viable capsules were applied. The symptom scores, level of Th1-type cytokine (IFN-gamma, IL-2) and Th2-type cytokine (IL-4, IL-10) and ratio of IFN-gamma to IL-4 were compared in two groups before and after treatment to analyze acupuncture effect.
RESULTSThe clinical symptoms were improved after one-week treatment in the acupuncture group (P<0.05), which had faster onset than the medicine group (P<0.05). The total effective rate was 90.48% (19/21) in the acupuncture group, which was superior to 78.95% (15/19) in the medicine group (P<0.05). Compared with medicine treatment, imbalanced condition of Th1/Th2 was turning towards the direction of Th2 after acupuncture, indicating a tendency to recover the balance.
CONCLUSIONThe clinical efficacy of acupuncture for D-IBS has close relationship with effectively improving balance of Th1/Th2 in patients with liver-stagnation and spleen-deficiency.