Expression and significance of P57(kip2) and Maspin in pathological scar.
- Author:
Yu-Mei CAI
1
;
Shi-Ze ZHU
;
Zhi-Fang ZHENG
;
Wei-Qun YANG
;
Wen-Yi WU
Author Information
- Publication Type:Journal Article
- MeSH: Cicatrix; metabolism; pathology; Cicatrix, Hypertrophic; metabolism; pathology; Cyclin-Dependent Kinase Inhibitor p57; metabolism; Fibroblasts; metabolism; Humans; Serpins; metabolism
- From: Chinese Journal of Plastic Surgery 2011;27(6):431-436
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of P57(kip2) and Maspin in the pathological scar and their possible role in the pathogenesis of abnormal scars.
METHODSImmunohistochemistry integrated image analysis and reverse transcription polymerase chain reaction (RT-RCR) were performed to detect the expression of P57(kip2) and Maspin in hypertrophic scar, keloid, mature scar and normal skin. Statistics was used to analyze the datas.
RESULTSThe expression of P57(kip2) protein was fixed to fibroblast intranuclear in abnormal scar, and the expression of P57(kip2) protein and P57(kip2) mRNA decreased (P < 0.05). The expression of Maspin protein was fixed to fibroblast cytoplasm and intranuclear in abnormal scar, and the expression of Maspin protein and Maspin mRNA decrease, compared with that in normal group (P < 0.05). There was positive correlation between P57(kip2) protein and Maspin protein expression (P < 0.01).
CONCLUSIONSThe decreased expression of P57(kip2) and Maspin in abnormal scar shows that they are cicatrix-related genes. There is a positive relationship between the two genes. It may be one of the mechanisms of pathogenesis of abnormal scar. It makes effect through fibroblasts.
