The therapeutic effect of propranolol with 1064 nm Nd: YAG laser on proliferating hemangioma in body surface.
- Author:
Ming TAN
1
;
Bo DUAN
;
Chun-mei ZHOU
;
Hao GONG
Author Information
- Publication Type:Journal Article
- MeSH: Angiogenesis Inhibitors; therapeutic use; Combined Modality Therapy; methods; Hemangioma; therapy; Humans; Lasers, Solid-State; therapeutic use; Propranolol; therapeutic use; Skin Neoplasms; therapy
- From: Chinese Journal of Plastic Surgery 2012;28(3):164-168
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the therapeutic effect of propranolol with 1 064 nm Nd:YAG laser on proliferating hemangioma in body surface.
METHODS97 patients with proliferating hemangiomas in body surface were randomly assigned to three groups: A group (32 patients were treated by propranolol with 1064 nm Nd:YAG laser), B group (35 patients were treated by 1064 nm Nd:YAG laser), C group (30 patients were treated by propranolol). Their visual analog scores, clinical outcomes and adverse events were compared respectively.
RESULTS18 weeks later, A group had a mean visual analog score of 65.50 +/- 16.55, compared with 54.03 +/- 20.13 in B group, 28.08 +/- 30.34 in C group (P < 0.05); 24 weeks later, the mean visual analog scores of three groups were 76.88 +/- 19.05, 63.89 +/- 19.43 and 45.48 +/- 31.86 (P < 0.05). After 24 weeks' treatment, 9 cases (28.1%) in A group, 3 cases (8.6%) in B group, 1 cases (4.0%) in C group obtained complete healing (P < 0.05). To effect of adverse events in body surface, the mean score of B group was higher than the scores of A group and C group (P < 0.05).
CONCLUSIONSPropranolol with 1064 nm Nd:YAG laser is effective and safe in the treatment of proliferating hemangioma.
