Autophagy Activity of CD34+ Cells in MDS Patients and Its Clinical Significance.
- Author:
Feng JIANG
1
;
Yuan-Yuan WANG
2
;
Jian-Nong CEN
3
;
Zi-Xing CHEN
1
;
Jian-Ying LIANG
1
;
Dan-Dan LIU
1
;
Jin-Lan PAN
1
;
Ming-Qing ZHU
1
;
Su-Ning CHEN
1
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD34; metabolism; Autophagy; Bone Marrow Cells; cytology; pathology; Flow Cytometry; Humans; Leukemia, Myeloid, Acute; pathology; Myelodysplastic Syndromes; pathology; Prognosis
- From: Journal of Experimental Hematology 2016;24(3):779-783
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the autophagy activity of CD34+ cells in bone marrow of MDS patients and its clinical significance.
METHODSThe activity of autophagy in bone marrow CD34+ cells from 20 MDS patients, 20 non-malignant anemia patients and 5 AML patients admitted in our hospital from October 2012 to March 2014 was detected by flow cytometry (FCM).
RESULTSThe autophagy activity in low risk MDS patients and non-malignant anemia patients were both significantly higher than that in both high risk MDS and AML patients (P<0.05), and more interestingly, the autophagy activity in MDS negatively correlated with World Health Organization classification-based prognostic system (WPSS) score (r=-0.877) .
CONCLUSIONThe autophagy activity CD34+ cells in the patients with MDS is higher than that in AML patients, and negatively correlated with WPSS scores, indicating that the decrease of autophagy activity maybe accelerate the genesis and development of MDS and relate with the prognosis of MDS patients.
