Relationship between Gene Polymorphism of HLA-A(*)/-B(*)-DRB1(*) and Aplastic Anemia in Chinese Han Population of Northwestern Plateau.

Ke Yang; Xiao-yu Guo; Xiao Han; Jian-feng OU; Hai Bai; Cun-bang Wang; Yao-zhu Pan

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Relationship between Gene Polymorphism of HLA-A()/-B()-DRB1(*) and Aplastic Anemia in Chinese Han Population of Northwestern Plateau.

Author: Ke YANG ¹ ; Xiao-Yu GUO ² ; Xiao HAN ³ ; Jian-Feng OU ¹ ; Hai BAI ⁴ ; Cun-Bang WANG ¹ ; Yao-Zhu PAN ¹
Author Information

1. Hematology Department and Institute of Hematology, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou 730050, Gansu Province, China.
2. Animal Experiment Department, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou 730050, Gansu Province, China.
3. Department of Hematology, The Second Affiliated Hospital of Lanzhou University, Lanzhou 730050, Gansu Province, China.
4. Hematology Department and Institute of Hematology, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou 730050, Gansu Province, China. E-mail: baihai98@hotmail.com.
Publication Type:Journal Article
MeSH: Alleles; Anemia, Aplastic; genetics; Asian Continental Ancestry Group; genetics; China; Female; Gene Frequency; HLA-DRB1 Chains; genetics; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic
From: Journal of Experimental Hematology 2016;24(3):795-800
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the correlation between the HLA genes and pathogenesis of aplastic anemia (AA), so as to find the susceptible AA genes.
METHODSPolymerase chain reaction with specific sequence primers (PCR-SSP) method was used to detect the HLA typing of 50 AA patients and 183 normal healthy individuals as controls in Chinese Han population of northwestern plateau.
RESULTSThe frequency of HLA-A* 0201 (45.0%), B* 1501 (11.0%), B* 5501 (9.0%) and DRB1* 0901 (19.0%) gene frequences in AA patients were significantly higher than those in controls (Odds Ratio: OR=1.657, 2.138, 2.314 and 1.932, x2=4.882, 3.876, 3.863 and 4.473 (P<0.05). In contrast, A* 0301 gene frequency (4.0%) in AA was significantly lower than that in controls, OR=0.349, x2=4.154 (P<0.05). The male HLA-A* 0201 gene frequency was lower than that in female (38.2% vs 59.4%), and the difference was statistically significant (P<0.05). Concludsion: The HLA-A* 0201, B* 1501, B* 5501 and DRB1* 0901 genes may be considered as the risk markers while A* 0301 gene as a protective marker of AA, the HLA-A* 0201 also shows the sex differences.