Correlation between Plasma microRNA Expression and Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.

Bin HU; Wei FU; Si-yong Huang; Xiao-tong Gao; Dan-hui LI; Xue-qian Yan; Yang-ping Zhang; Qiang Liu; Li Liu; Ying-min Liang

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Correlation between Plasma microRNA Expression and Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.

Author: Bin HU ¹ ; Wei FU ² ; Si-Yong HUANG ¹ ; Xiao-Tong GAO ¹ ; Dan-Hui LI ¹ ; Xue-Qian YAN ¹ ; Yang-Ping ZHANG ¹ ; Qiang LIU ¹ ; Li LIU ¹ ; Ying-Min LIANG ³
Author Information

1. Department of Hematology, Tangdu Hosipital, Fourth Military Medical Uiniversity, Xi'an 710038, Shaanxi Province, China.
2. Department of Hematology, Forty-fourth Hospital of Chinese PLA, Guiyang 550009, Guizhou Province, China.
3. Department of Hematology, Tangdu Hosipital, Fourth Military Medical Uiniversity, Xi'an 710038, Shaanxi Province, China. E-mail: liangym@fmmu.edu.cn.
Publication Type:Journal Article
MeSH: Biomarkers; blood; Graft vs Host Disease; blood; pathology; Hematopoietic Stem Cell Transplantation; Humans; MicroRNAs; blood; Real-Time Polymerase Chain Reaction; Up-Regulation
From: Journal of Experimental Hematology 2016;24(3):827-832
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the microRNA (miRNA) expression in plasma of patients with aGVHD and without aGVHD after allo-hematopoietic stem cell transplantation (allo-HSCT).
METHODSThe miRNAs (miR-423, mirR199a-3p, miR93*, miR377) expression levels in peripheral blood plasma of 25 patients before and after allo-HSCT were detected by real-time PCR.
RESULTSmiR-423, miR199a-3p and miR-93* in aGVHD group were significantly upregulated (P<0.05); miR-377 expression was not significantly different between aGVHD and non-aGVHD (P>0.05).
CONCLUSIONThe expression of miR-423, miR-199a-3p, miR-93* are upregulated in aGVHD group, which can be used as biomarkes to monitor and to diagnose aGVHD.