Research Progress on the Role of Chromatin Remodeling Factor BRG1 in Acute Myeloid Leukemia.
10.7534/j.issn.1009-2137.2016.03.054
- Author:
Shuo GAO
1
;
Xue-Jing XU
1
;
Kui ZHANG
2
Author Information
1. Department of Clinical Laboratorial Examination, Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210000, China.
2. Department of Clinical Laboratorial Examination, Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210000, China. E-mail: zhangkui6103@163.com.
- Publication Type:Journal Article
- MeSH:
Chromatin;
Chromatin Assembly and Disassembly;
DNA Helicases;
genetics;
Humans;
Leukemia, Myeloid, Acute;
genetics;
Neoplastic Stem Cells;
cytology;
Nuclear Proteins;
genetics;
Transcription Factors;
genetics
- From:
Journal of Experimental Hematology
2016;24(3):930-933
- CountryChina
- Language:Chinese
-
Abstract:
BRG1 (Brahma-related gene 1, BRG1) is the ATPase subunit of SWI/SNF chromatin remodeling complexes, which plays an important role in cell cycle regulation, DNA repair and tumor development. Unlike the evidence as tumor suppressor genes in the past reports, latest researches show that BRG1 plays an important role in sustaining the growth of leukemia cells in acute myeloid leukemia, and these effects on normal hematopoietic stem cells are dispensable. Further studies of the role and mechanism of BRG1 in acute myeloid leukemia will contribute to the development of a new and promising targeted therapy strategy. This article reviews the role of BRG1 on leukemia cells and leukemia stem cells in AML and discusses the related mechanism, which providing some reference for the targeted treatment strategy of AML.
