Mutation of IL-7R in Adult Patients with T-cell Acute Lymphoblastic Leukemia and Its Clinical Significance.
- Author:
Li-Chan XIAO
1
;
Min LI
1
;
Zheng GE
2
;
Yan GU
1
;
Xi-Lian ZHOU
1
;
Xing GUO
1
;
Jian-Yong LI
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Exons; Humans; Mutation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Interleukin-7
- From: Journal of Experimental Hematology 2016;24(4):1014-1018
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEInterleukin 7 (IL-7) and its receptor（IL-7R）are essential for normal T-cell development and homeostasis. This study was aimed to investigate the IL-7R mutation and its clinical significance in adult patients with adult acute lymphoblastic leukemia (ALL), particularly in T-ALL.
METHODSThe exons of IL-7R were amplified, cloned and sequenced in 144 adult patients with ALL; the frequency, position and lypes of IL-7R mutation were detected and their correlation with clinical features was analyzed.
RESULTS7.3% of T-ALL and 1.1% of B-ALL showed somatic IL-7R mutations which located at exon 6 and exon 5, respectively. Moreover, the IL-7R mutation was associated with poor clinical outcome in adult ALL patients. Furthermore, the co-existence of IL-7R mutation with NOTCH1 mutations and/or PHF6 mutation in T-ALL was observed.
CONCLUSIONIL-7R mulation and its associated signaling pathways may play an important role in the pathogenesis of T-ALL.
