Analysis of Clinical Feature and Curative Efficacy of 30 Patients with T Cell Lymphoblastic Lymphoma.
- Author:
Ping YANG
1
;
Wei ZHAO
1
;
Hong-Mei JING
1
;
Kai HU
1
;
Wei WAN
1
;
Ji-Jun WANG
1
;
Xiao-Yan KE
2
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Retrospective Studies; Survival Rate; Young Adult
- From: Journal of Experimental Hematology 2016;24(4):1056-1060
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze clinical feature and curative efficacy of patients with T cell lymphoblastic lymphoma(T-LBL).
METHODSThe clinical data including clinical features, laboratorial results, survival and prognostic factors from 30 patients with T-LBL were retrospectively analyzed.
RESULTSMedian age of 30 cases was 24.5 years, 25 (83.3%) patients were at high-intermediate and high risk by IPI, extranodal disease was present in 73.3% of the patients, 17(56.7%) patients had bone marrow involvement and 19(63.3%) had mediastinal masses. The overall response rate(ORR) for the whole group was 80.0%, the complete response rate was 36.7%, the 3-5-year overall survival rate was 37.1% and 26.0%, respectively. Compared with NHL-like regimens, ALL-like chemotherapy could improve the survival of patients, the 3-year overall survival rate was 59.1% vs 27.3%. For adult patients, the median overall survival time was 35 months vs 13 months in HSCT group and chemotherapy group, there was a statistically significant difference(P=0.019). ECOG score, IPI score, anemia, the level of LDH and β2-MG, therapy regimens, the short-term efficacy and the level of fibrinogen were the related factors for prognosis.
CONCLUSIONT-LBL is more common in young men, with large mediastinal mass and bone marrow involvement. ALL-like chemotherapy regimens are superior to NHL-like regimens, HSCT can improve the survival and reduce the recurrence of adult patients. Chemotherapy combined with allogeneic DC/CIK immune cell treatment can be used in relapsed patients.