Research Progress on Inflammasome and Cancer-associated Thrombosis-Review.
10.7534/j.issn.1009-2137.2016.04.056
- Author:
Jing-Zheng ZHANG
1
;
Jian GU
2
Author Information
1. Institute of Hematology, Clinical Medical College of Yangzhou University,Subei People's Hospital of Jiangsu Province,Yangzhou 225001,Jiangsu Province,China.
2. Institute of Hematology, Clinical Medical College of Yangzhou University,Subei People's Hospital of Jiangsu Province,Yangzhou 225001,Jiangsu Province,China.E-mail：maolujiu918@163.com.
- Publication Type:Journal Article
- MeSH:
Heat-Shock Proteins;
Humans;
Inflammasomes;
Inflammation;
NF-kappa B;
Neoplasms;
Thrombosis
- From:
Journal of Experimental Hematology
2016;24(4):1260-1263
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasome is a complex of protein, which can recognize pathogen molecules and pathogens simulating human heat shock protein via pattern recognition receptors, thus it causes their own activation, sensitizes NF-κB pathway, induces the production of inflammatory mediators, leads the chronic inflammation and promotes thrombosis. Some studies reported that nearly 17% of the new tumors can be caused by chronic inflammation, and it seems that there is a complicated relationship between inflammasome and cancer-associated thrombosis.This article summarizes the correlation between inflammasome and cancer-associated thrombosis, and some of these theories have confirmed the relationship between them.
