Development of Regulatory T Cells Mediated by NF-κB and Its Role in GVHD -Review.
10.7534/j.issn.1009-2137.2016.04.060
- Author:
Hai-Ying ZHANG
1
,
2
;
Qiang ZHAO
1
;
Tao WU
1
;
Author Information
1. Department of Hematology, Center of Hematologic Diseases of Chinese PLA
2. Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
- Publication Type:Journal Article
- MeSH:
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Humans;
NF-kappa B;
T-Lymphocytes, Regulatory
- From:
Journal of Experimental Hematology
2016;24(4):1280-1283
- CountryChina
- Language:Chinese
-
Abstract:
Graft versus host disease (GVHD) is the major complication of allogenic hematopoietic stem cell transplantation (allo-HSCT), and is a mainly responsible result for the non-recurrence-related mortality of long-term survived patient after transplantation. Studies indicated that regulatory T (Treg) cells can inhibit early-GVHD. Since the transcriptional factor NF-κB has been implicated in the regulation of Treg cell proliferation and activation, it becomes a potential target of GVHD therapy. Thus, in this review the function and signaling pathway of NF-κB, as well as the relationship between GVHD and NF-κB, are discussed and summarized.
