Anticancer effects of Pingyangmycin-activated carbon nanoparticles against human oral squamous carcinoma Tca8113 and BcaCD885 cell lines in vitro.
- Author:
Ming-lei SUN
1
;
Chang-mei WANG
;
Yu-ming WEN
Author Information
- Publication Type:Journal Article
- MeSH: Antibiotics, Antineoplastic; Bleomycin; analogs & derivatives; Carbon; Carcinoma, Squamous Cell; Cell Line; Cell Line, Tumor; Humans; In Vitro Techniques; Mouth Neoplasms; Nanoparticles
- From: West China Journal of Stomatology 2010;28(3):257-260
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe cytotoxic effects of a new formulation of Pingyangmycin-activated carbon nanoparticles (PYM-CH-NP) on two human oral squamous cell carcinoma Tca8113 and BcaCD885 cell lines were studied in vitro.
METHODSThe inhibitory effects of PYM-CH-NP and Pingyangmycin (PYM) were evaluated by methyl thiazolyl tetrazolium (MTT) assay at 1-7 days. The 50% inhibition concentration values (IC50) and relative antitumor activity (RAA) of PYM-CH-NP and PYM against Tca8113 and BcaCD885 with different drug concentration were evaluated. The time-dependent cytotoxic effects of PYM-CH-NP and PYM were during 1-5 days, so the doseeffect relationship was investigated at 5th day.
RESULTSBoth PYM-CH-NP and PYM had high anticancer effects on Tca8113 and BcaCD885, and the cytotoxic effects were dose-dependent and time-dependent.
CONCLUSIONThe activated carbon nanoparticles (CH-NP) may serve as a new drug delivery carrier of PYM. The new formulation PYM-CH-NP could slow down drug release, prolonged the drug concentration and its acting time, so more effective anticancer efficacy could be achieved.
