Association between interferon regulatory factor 6 gene polymorphism and non-syndromic oral clefting.
- Author:
Hong-wang REN
1
;
Gui-zhi ZHAO
;
Yong-qing HUANG
;
Min MA
;
Jian MA
;
Yan-bo SUN
;
Jun GAO
;
Bing SHI
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Cleft Palate; genetics; Humans; Interferon Regulatory Factors; genetics; Polymorphism, Genetic
- From: West China Journal of Stomatology 2010;28(4):352-360
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between interferon regulatory factor 6 (IRF6) gene polymorphism and non-syndromic oral clefting (NSOC).
METHODSExperimental group consisted of 186 Ningxia NSOC patients, their parents (183 fathers and 174 mothers), 172 core families (patient+parents), and control group consisted of 200 normal children. DNA was extracted and PCR-restriction fragment length polymorphism (PCR-RFLP) was used to identify the genotypes of the samples, case-control analyses and transmission-disequilibrium test (TDT) were carried out.
RESULTSCompared with control group, there were significant differences in both rs642961's and rs4844880's AA genotype and A allele among NSOC patients (P < 0.05), but no difference in cleft palate (P = 0.15, P = 0.967, respectively). In TDT analysis, the A allele of rs642961 had a strong over-transmission in NSOC (P < 0.05), so did the rs4844880'A allele (P < 0.05), but neither of them had significant difference in cleft palate (P = 0.91, P = 0.95, respectively).
CONCLUSIONIRF6 gene polymorphism is associated with NSOC.
