Review on the research progress of the role of miRNAs in gastric cancer.
- Author:
Xiaohui PANG
1
;
Ming LIU
;
Feng BI
Author Information
1. Laboratory of Signal Transduction & Molecular Targeted Therapy/Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Gene Expression Regulation, Neoplastic;
genetics;
Humans;
Neoplasm Metastasis;
genetics;
RNA Interference;
RNA, Small Interfering;
biosynthesis;
genetics;
Stomach Neoplasms;
genetics;
metabolism;
pathology
- From:
Journal of Biomedical Engineering
2012;29(4):780-802
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs, known as small noncoding MiRNAs, 19 to 24 nt in length, are important gene regulators and recognized as key players in carcinogenesis. The mechanism lies in that the MiRNAs can conjugate with their targeted mRNA and then lead to the targeted mRNA degradation or repress their translation. Bioinformatic analysis indicates that each MiRNA can regulate hundreds of gene targets and could serve functionally as "oncogenes" or "tumor suppressor genes", and therefore regulate multiple cellular processes relevant to carcinogenesis and cancer progression. Up to now, there have been a lot of studies about the MiRNAs which may play an important role in stomach neoplasms. The purpose of this paper is to have a review of the present studies on the MiRNAs related to stomach neoplasms, in order set basis for further study and their clinical application.
