Research progress of abnormal phosphorylation of microtubule-associated tau protein and of the targeted inhibition of the phosphorylation.
- Author:
Futao ZHOU
1
;
Shuangrong CHEN
;
Xuechuan SUN
Author Information
1. School of Physical Education, Nanchang Hangkong University, Nanchang 330063, China.
- Publication Type:Journal Article
- MeSH:
Alzheimer Disease;
metabolism;
physiopathology;
Glycogen Synthase Kinase 3;
antagonists & inhibitors;
metabolism;
Humans;
Neurodegenerative Diseases;
metabolism;
physiopathology;
Phosphoric Monoester Hydrolases;
metabolism;
Phosphorylation;
Protein Kinases;
metabolism;
tau Proteins;
chemistry;
metabolism;
physiology
- From:
Journal of Biomedical Engineering
2012;29(4):788-792
- CountryChina
- Language:Chinese
-
Abstract:
Progressive dementia is described as the first and most prominent symptom of Alzheimer's disease (AD), and hyperphosphorylation of microtubule associated Tau protein (MAPT) plays a key role in neurodegeneration and neuronal dysfunction in AD and other neurodegenerative diseases. This paper reviews several protein kinases and phosphatases which can phosphorylate/dephosphorylate Tau protein, and evaluates a therapeutic strategy based on targeted inhibition of Tau kinases and activation of Tau phosphatases.
