Research on the stability of vitamin C in non-aqueous carrier.
- Author:
Chao YOU
1
;
Bo FANG
;
Wei ZHANG
Author Information
1. Lab of Chemical Engineering Rheology, Chemical Engineering Research Center, East China University of Science and Technology, Shanghai 200237, China.
- Publication Type:Journal Article
- MeSH:
Ascorbic Acid;
chemistry;
Carrageenan;
Drug Carriers;
chemistry;
Drug Stability;
Glycerol;
chemistry;
Oxidation-Reduction;
Solutions
- From:
Journal of Biomedical Engineering
2012;29(5):929-932
- CountryChina
- Language:Chinese
-
Abstract:
Glycerin containing carrageenan as a non-aqueous carrier for vitamin C (Vc) was prepared in this study. The stabilities of Vc at room temperature and after high temperature accelerating treatment were investigated. The effects of Vc as well as carrageenan on rheological properties were analyzed. The results showed that, with the increases of Vc, the viscosity of the non-aqueous system decreased and the shear-thinning phenomenon disappeared. Furthermore, the stability of Vc was kept well in this non-aqueous system, and the retention rate maintained at a high level-over 99% a month later in room temperature, and over 97% after high temperature accelerating treatment for 20 days. The retention rate of Vc was improved with the increasing of carrageenan. It was proved that this non-aqueous system was an ideal drug delivery system for Vc.
