The mechanism of HBV disruption on RIG-I signaling pathway.
- Author:
Libo YAN
1
;
Feijun HUANG
;
Hong TANG
Author Information
1. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
DEAD Box Protein 58;
DEAD-box RNA Helicases;
metabolism;
Gene Products, pol;
metabolism;
Hepatitis B;
immunology;
Humans;
Immunity, Innate;
immunology;
Signal Transduction;
Trans-Activators;
metabolism
- From:
Journal of Biomedical Engineering
2012;29(5):995-1013
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection disrupt the innate immunity response, which may play an important role in the chronic mechanism, while retinoic acid-induced gene I (RIG-I) mediated signaling pathway is one of the most important channel in the innate immunity. HBx and HBV polymerase may disrupt RIG-I mediated signaling pathway. The recent advances about HBV and RIG-I are reviewed in this article.
