Bullous Pemphigoid in an Elderly Patient with Myelodysplastic Syndrome and Refractory Anemia Coupled with Excess of Blast.
10.5021/ad.2011.23.S3.S390
- Author:
Yin Yin LEE
1
;
Ping Chong BEE
;
Chew Kek LEE
;
Manimalar NAIKER
;
Rokiah ISMAIL
Author Information
1. Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia. yleemd@yahoo.com
- Publication Type:Case Report
- Keywords:
Anemia;
refractory;
with excess blast;
Myelodysplastic syndromes;
Paraneoplastic syndromes;
Pemphigoid;
bullous
- MeSH:
Aged;
Anemia;
Anemia, Refractory;
Anemia, Refractory, with Excess of Blasts;
Azathioprine;
Basement Membrane;
Biopsy;
Blister;
Fluorescent Antibody Technique, Direct;
Hematologic Neoplasms;
Humans;
Immunoglobulin G;
Male;
Myelodysplastic Syndromes;
Paraneoplastic Syndromes;
Pemphigoid, Bullous;
Prednisolone;
Skin
- From:Annals of Dermatology
2011;23(Suppl 3):S390-S392
- CountryRepublic of Korea
- Language:English
-
Abstract:
Bullous pemphigoid (BP) has a recognized association with solid organ tumors, but is relatively rare in hematological malignancies. We report a 67-year-old male who developed BP after being diagnosed with myelodysplastic syndrome and refractory anemia with excess of blast (RAEB). Skin biopsy elucidated sub-epidermal bulla using direct immunofluorescence, revealing linear C3 and IgG deposits along the basement membrane. His BP was recalcitrant to the conventional treatment and only responded to a combination of high dose oral prednisolone and azathioprine. The relative refractory nature of his condition and concurrent RAEB supports a paraneoplastic nature.
