The curative effect and safety of collagen sponge with different pH and content of protein implanted into orthopedic bone defect.
- Author:
Gang TONG
1
;
Jing LEI
;
Cuihong ZHONG
;
Weixin CAI
;
Xuewei LIN
Author Information
1. Guangzhou Trauer Biotechnology Company, Guangzhou 510663, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Collagen Type I;
adverse effects;
chemistry;
therapeutic use;
Hydrogen-Ion Concentration;
Male;
Prostheses and Implants;
Proteins;
analysis;
Rabbits;
Radius Fractures;
surgery
- From:
Journal of Biomedical Engineering
2012;29(6):1125-1130
- CountryChina
- Language:Chinese
-
Abstract:
This paper presents a 3mm fracture model of radial bone of rabbits using operation method. The bone defect was treated with collagen sponge with different pH and different content. After the operation, the body temperature, blood routine measurement, serum antibody, X-ray examination and histological observation in each group were examined to evaluate and study the curative effect and safety of collagen sponge. Collagen sponge had a good result of safety, but there was slightly change in blood routine, serum antibody, and histological observation, etc, with the pH changing and different content of collagen. The results showed that there was no obvious influence of safety to tissues after treatment of the collagen sponge at different pH implanted into bone defect. Collagen sponge at lower pH could promote the healing of bone defect partly, while the safety of collagen sponge with lower content was better.
