Genetic alterations in MAPK and PI3K/Akt signaling pathways and the generation, progression, diagnosis and therapy of thyroid cancer.
- Author:
Bin LIU
1
;
Anren KUANG
Author Information
1. Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Extracellular Signal-Regulated MAP Kinases;
genetics;
metabolism;
Humans;
MAP Kinase Signaling System;
genetics;
Mitogen-Activated Protein Kinases;
genetics;
metabolism;
Mutation;
Phosphatidylinositol 3-Kinases;
genetics;
metabolism;
Proto-Oncogene Proteins c-akt;
genetics;
metabolism;
Signal Transduction;
genetics;
physiology;
Thyroid Neoplasms;
genetics;
physiopathology;
therapy
- From:
Journal of Biomedical Engineering
2012;29(6):1221-1225
- CountryChina
- Language:Chinese
-
Abstract:
The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phoshoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling pathways play a major role in regulating cell growth, proliferation and apoptosis, via transmission of cell signals to cell nucleus. The genes, coding the MAPK/ERK and PI3K/Akt signaling cascade proteins, are significantly mutated in thyroid cancer. Genetic alternations contribute to aberrant activations and interaction of MAPK/ERK and PI3K/Akt signaling pathways in consequence of malignant follicular cell transformation and progression. This review focuses mainly on the role of genetic alterations in coding MAPK/ERK and PI3K/Akt signaling pathway proteins in generation, progression and diagnosis of thyroid cancer. Moreover, it additionally points out a therapeutic potential in restoring iodine avidity of thyroid cancer cells for radionuclide targeted treatment, by synergistically inhibiting activity of signaling pathways.
