Study on the immuno-effects of recombinant hepatitis B vaccination in adults.
- Author:
Feng-mei ZHANG
1
;
Qing-xin ZHAO
;
Jing-hua HAN
;
Quan-he ZHOU
;
Mao-ci WANG
;
Wei MIAO
;
Ruo LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Hepatitis B; prevention & control; Hepatitis B Antibodies; blood; Hepatitis B Core Antigens; immunology; Hepatitis B Surface Antigens; immunology; Hepatitis B Vaccines; immunology; Humans; Male; Middle Aged; Vaccination; Vaccines, Synthetic; immunology
- From: Chinese Journal of Epidemiology 2003;24(8):697-699
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the immuno-effects of hepatitis B (HB) vaccination in adults.
METHODSFive groups were sampled by means of cluster sampling, and serum HBsAg, anti-HBs and anti-HBc were tested in every group at people aged from 18 to 50. Recombinant HB vaccine was injected to the ones that HBsAg, anti-HBs and anti-HBc were all negative. Concentration of anti-HBs in serum was tested after one year and three years of vaccination. Immuno-effects of recombinant HB vaccination in adults at different ages and between sexes, were then calculated.
RESULTSGood immuno-effects of recombinant HB vaccination in adults were noticed. After one year and three years of vaccination with 5 micro g recombinant HB vaccine, the anti-HBs positive rates were 82.76%, 70.77% while the serum concentrations of anti-HBs were 55.91 mIU/ml and 35.41 mIU/ml respectively. When 10 micro g was used, the concentrations were 83.74%, 72.22%, 56.89 mIU/ml and 30.29 mIU/ml respectively. The effects did not show significant differences between different doses on 10 micro g and of 5 micro g. Concentration of anti-HBs reduced when time went by. The factors such as age and sex influenced the effects of immunity on recombinant HB vaccination.
CONCLUSIONGood immunity could be obtained when recombinant hepatitis B was vaccinated in vulnerable population aged 18 to 50.
