A study on genetic epidemiology of cerebral infarction.
- Author:
Bao-lin SHI
1
;
Yong ZHANG
;
Yan-hua WU
;
Jie ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Case-Control Studies; Cerebral Infarction; epidemiology; genetics; China; epidemiology; Family Health; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Prevalence
- From: Chinese Journal of Epidemiology 2003;24(8):719-721
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor.
METHODSA matched case-control study including 112 pairs pedigrees was carried out. Using the Li-Mantel-Gart method and the Falconer method to estimate the segregation ratio and the heritability of cerebral infarction.
RESULTSThe prevalence rate of the first-degree and the second-degree relatives in cases was significantly higher than that in controls. The segregation ratio was 0.143 7 (0.113 0 - 0.174 4), significantly lower than 0.25, which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the first-degree and the second-degree relatives were 47.84% and 40.95% higher in male's than in female's.
CONCLUSIONCerebral infarction was a polygenetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males.
