Study on the correlation between the different papillomavirus type and telomerase in cervical cancer.
- Author:
Wen LV
1
;
Guang-Mei ZHANG
;
Li-Hua SUI
;
Jing WANG
Author Information
- Publication Type:Journal Article
- MeSH: Cervical Intraepithelial Neoplasia; enzymology; pathology; virology; Female; Humans; Neoplasm Staging; Papillomaviridae; isolation & purification; Telomerase; metabolism; Uterine Cervical Neoplasms; enzymology; pathology; virology
- From: Chinese Journal of Epidemiology 2003;24(10):924-927
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo define a correlation between different human papillomavirus (HPV) types and telomerase activity in cervical cancer.
METHODSTelomerase activity was detected by TRAP-PCR, and different HPV type was determined by PCR in 83 cervical cancer, 47 cervical intraepithelial neoplasia (CIN) and 10 normal cervix cases.
RESULTSWith regard to positive rates of telomerase and HPV 16/18: the results were cervical cancer > CIN > normal cervix, CIN III > CIN I, II; with regard to HPV 6/11 positive rate: the results showed CIN I, II > CIN III. Positive rates of telomerase cervical cancer and HPV were bearing on grading and staging, but they did not correlate with histologic subtypes. Positive rate of HPV 6/11 had nothing to do with grading, staging and histologic patterns. On expression strength of telomerase and HPV 16/18: the results showed cervical cancer > CIN, CIN III > CIN I, II. Regard to HPV 6/11'expression strength: the results showed CIN I, II > CIN III, CIN > cervical carcinoma.
CONCLUSIONHPV 16/18 infection seemed to have played an important role in carcinogenesis of cervical lesions by activation of telomerase.
