Increase in concentration of soluble HLA-G in high-quality embryos after intracytoplasmic sperm injection.
10.5115/acb.2011.44.4.331
- Author:
Mohammad Hassan HEIDARI
1
;
Marefat Ghaffari NOVIN
;
Farzaneh AHMADI
;
Mehran KHORSHID
;
Tohid NAJAFI
;
Aidin MOLOUKI
;
Saghar SALEHPOUR
;
Mojgan BANDEHPOUR
;
Matineh HEIDARI
;
Eimi SATO
Author Information
1. Department of Anatomy, Shahid Beheshti Medical University, Velenjak, Tehran, Iran. hdr@sbmu.ac.ir
- Publication Type:Original Article
- Keywords:
HLA antigen;
Assisted reproductive techniques;
Intracytoplasmic sperm injections
- MeSH:
Culture Media;
Embryonic Structures;
HLA-G Antigens;
Humans;
Leukocytes;
Pregnancy;
Pregnancy Rate;
Reproductive Techniques;
Reproductive Techniques, Assisted;
Sperm Injections, Intracytoplasmic
- From:Anatomy & Cell Biology
2011;44(4):331-336
- CountryRepublic of Korea
- Language:English
-
Abstract:
Non-invasive methods are normally preferred to conventional invasive methods when selecting suitable embryos to improve pregnancy rates after assisted reproduction techniques. One of the most recognized non-invasive methods is to examine the supernatants of embryo culture media. Soluble human leukocyte antigen, class I, G (sHLA-G) antigen is a non-classical class I molecule that has been widely considered as a marker of pregnancy failure or implantation success. In the current study of some Iranian patients, we examined the concentration of sHLA-G at different time points after intracytoplasmic sperm injection and compared the rates to the morphology and quality of the selected embryos. We showed that the concentration of sHLA-G increases over time in high-quality embryos. We conclude that there is a positive relationship between morphology, quality, and sHLA-G concentration. We suggest that this relationship can be used to increase the chance of a successful pregnancy.
