Study on EB virus infection, LMP1 and Bcl-2 expression in lung cancer patients.
- Author:
Cui-mei LI
1
;
Shu-jie ZHANG
;
Jian-hua ZHU
;
Guang-liang HAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Epstein-Barr Virus Infections; genetics; metabolism; pathology; virology; Gene Expression Regulation, Viral; Herpesvirus 4, Human; genetics; physiology; Humans; Lung Neoplasms; genetics; metabolism; pathology; virology; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; genetics; metabolism; Viral Matrix Proteins; genetics; metabolism
- From:Chinese Journal of Experimental and Clinical Virology 2011;25(4):277-279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the Epstein-Barr virus (EBV) infection, the expression of EBV latent membrane protein 1 ( LMPl) and oncogene bcl-2 in lung cancer patients.
METHODSEBERI in 108 cases of lung cancer were detected with in situ hybridization. EBV positive and negative lung cancer tissues were analysed for the expression of LMP1 and Bcl-2 by immnohistochemistry. The average area (AA) and integral optical density (IA) of each sample was measured with the digital medical image analyzing system.
RESULTSIn 108 cases of lung cancer, 36 cases were EBER1 positive and 7 cases were LMP1 positive. The expression of Bcl-2 was higher in EBV positive lung cancer tissues than that in EBV negative. The AA value was 58014.23 +/- 6918.45 and 38156.22 +/- 4096.79, while the IA value was 11.00 +/- 1.48 and 8.03 +/- 0.78 respectively. No statistic difference was fund in the expression of Bcl-2 betwen LMP1 positive and negative lung cancer tisssues.
CONCLUSIONEBV infection in lung cancer increased the expression of bcl-2, which may play a role in the occurrence or development of lung cancer. The increased expression of Bcl-2 may not be induced by LMP1. The exact mechanism need further study.
