Clinical study on viral hepatitis combined with aplastic anemia
10.3760/cma.j.issn.1003-9279.2011.04.014
- VernacularTitle:病毒性肝炎合并再生障碍性贫血的临床研究
- Author:
Yao LU
1
;
Yan-Li ZHANG
;
Ge SHEN
;
Lu ZHANG
;
Lin WANG
;
Guo-Hua QIU
;
Yun-Zhong WU
;
Min YANG
;
Ming-Hui LI
Author Information
1. 首都医科大学附属北京地坛医院
- Keywords:
Hepatitis,viral,human;
Anemia,aplastic;
Diagnosis
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(4):283-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical features, outcomes and treatments of viral hepatitis combined with aplastic anemia. Methods25 cases diagnosed as viral hepatitis combined with aplastic anemia in Beijng Ditan Hospital between April 2004 and September 2009 were retrospectively analyzed. In this group of patients aplastic anemia was finally diagnosed by bone marrow aspiration. We collected clinical data of these patients, including a history of liver disease, drug allergies, hospital medication history, laboratory data, and then performed descriptive analysis. Results25 patients with viral hepatitis were diagnosed as complicated with aplastic anemia by histopathological data. Among these patients, 17 were male and 8 were women. Viral hepatitis included: chronic hepatitis B ( 12 cases), chronic hepatitis C (4 cases), acute hepatitis E ( 1 case), hepatitis caused by CMV infection ( 1 case), and unclassified hepatitis (7 cases). Among these patients, 7 were diagnosed as severe hepatitis. Considering previous history, only 3patients had history of short-term interferon therapy before hospitalization, and the remaining patients did not use drug that affects blood system. Treatments were as followings: using colony stimulating factor in 6patients, gamma globulin in 9 patients, glucocorticoids in 3 patients, erythropoietin in 1 patient, only oral drug to raise erythrocytes in 2 patients, red blood cells transfusion in 6 patients, platelets transfusion in 2patients. As for clinical outcomes, 20 patients acquired improved condition and were discharged, 3 patients were discharged voluntarily and 2 patients died of severe hepatitis combined with other complications.Conclusion Main treatments of viral hepatitis combined with aplastic anemia were to treat primary hepatopathy and nucleoside analogue-based antiviral therapy, to provide symptomatic and supportive treatment for blood diseases. Blood diseases would recover simultaneously while liver disease was improved, and the prognosis was good.
