Significance of serum golgi protein 73 (GP73), alpha-fetoprotein (AFP) and lectin-reactive alpha-fetoprotein (AFP-L3) expresssion in primary hepatic carcinoma.
- Author:
Wen-fang XU
1
;
Ying-ming FEI
;
Jian-kang ZHOU
;
Hua-jing SHEN
;
Xue-fang CHEN
;
Qiu-qiong LV
;
Yu-yun DING
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; blood; genetics; Carcinoma, Hepatocellular; blood; diagnosis; genetics; metabolism; Diagnostic Tests, Routine; methods; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; blood; diagnosis; genetics; metabolism; Male; Membrane Proteins; blood; genetics; Middle Aged; Protein Isoforms; blood; genetics; metabolism; Young Adult; alpha-Fetoproteins; genetics; metabolism
- From:Chinese Journal of Experimental and Clinical Virology 2011;25(4):286-288
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the alone and joint diagnostic value of serum golgi protein 73 (GP73), alpha-fetoprotein (AFP) and the percentage of lectin-reactive aipha-fetoprotein (AFP-L3) of primary hepatic carcinoma (PHC), and provide a novel method for diagnosis for PHC and screening for high-risk population.
METHODSELISA was used to detect the serum level of GP73, AFP and AFP-L3% in 81 cases of PHC,176 cases chronic hepatitis and liver cirrhosis, 30 cases other tumber cancer and 40 cases of health people.
RESULTSThe sensitivity of GP73, AFP and AFP-L3% in PHC is 77.78%, 62.69% and 51.85%, and the specificity is 84.55%, 86.99% and 96.34%, respectively. Joint detection could increase the sensitivity up to 88.89%.
CONCLUSIONGP73 was a high sensitivity mark for dignosis of PHC, while AFP-L3% was a high specificity mark for dignosis of PHC. The joint detection could improve PHC diagnostic performance.
