Significance of serum golgi protein 73 ( GP73 ), alpha-fetoprotein (AFP) and lectin-reactive alphafetoprotein (AFP-L3) expresssion in primary hepatic carcinoma
10.3760/cma.j.issn.1003-9279.2011.04.015
- VernacularTitle:血清GP73、AFP和AFP-L3联合检测在原发性肝癌诊断中的价值
- Author:
Wen-Fang XU
1
;
Ying-Ming FEI
;
Jian-Kang ZHOU
;
Hua-Jing SHEN
;
Xue-Fang CHEN
;
Qiu-Qiong LV
;
Yu-Yun DING
Author Information
1. 绍兴市第六人民医院
- Keywords:
Liver neoplasms;
Carcinoma,hepatocellular;
Golgi apparatus,proteins;
Alphafetoproteins
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(4):286-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the alone and joint diagnostic value of serum golgi protein 73 (GP73), alpha-fetoprotein ( AFP) and the percentage of lectin-reactive alpha-fetoprotein ( AFP-L3 ) of primary hepatic carcinoma (PHC) ,and provide a novel method for diagnosis for PHC and screening for highrisk population. Methods ELISA was used to detect the serum level of GP73, AFP and AFP-L3％ in 81 cases of PHC, 176 cases chronic hepatitis and liver cirrhosis , 30 cases other tumber cancer and 40 cases of health people. Results The sensitivity of GP73, AFP and AFP-L3％ in PHC is 77.78％ ,62.69％ and 51.85％ ,and the specificity is 84. 55％ ,86. 99％ and 96. 34％ ,respectively. Joint detection could increase the sensitivity up to 88.89％. Conclusion GP73 was a high sensitivity mark for dignosis of PHC, while AFP-L3％ was a high specificity mark for dignosis of PHC. The joint detection could improve PHC diagnostic performance.
