Comparative study on the clinical characteristics of HBV/HCV co-infection patients with different HCV contaminnation mode
10.3760/cma.j.issn.1003-9279.2011.04.021
- VernacularTitle:不同HCV感染途径HBV/HCV重叠感染患者临床差异分析
- Author:
Ka ZHANG
1
;
Hong CAO
;
Xiao-An YANG
;
Xiao-Lu HONG
;
Lu-Biao CHEN
;
Xin SHU
;
Gang LI
;
Qi-Huan XU
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis B,chronic;
Liver Cirrhosis;
Hepacivirus;
Infections
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(4):301-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study was to compare the epidemiological, biochemical and virological characteristics among patients co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) according to the mode of HCV contamination. MethodsThe study included 133 patients with chronic HBV/HCV co-infection. They were studied and subdivided into two groups ( drug addicts group and Blood transfusion group) according to the mode of HCV contaminnation. The epidemiological, biochemical and virological characteristics were collected. Univariate analysis was performed with the SPSS 16.0. Results 78 patients were infected by the mode of drug addicts(IDU) , whereas 55 were infected by the mode of blood transfusion(PTCH). Patients in drug addicts group had yonger age, shorter HBV and HCV infection history, and lower cirrhosis percentage than those of patients in PTCH group( P ＜ 0. 05 ). However, serum levels of ALT ( t = 4. 760, P = 0. 000 ), AST( t = 3. 798, P--0. 000 ), TBil ( t = 4. 274, P = 0. 000 ) of IDU patients were higher than those of PTCH patients. There was difference of sex composition between two groups (x2 = 18. 706,P =0. 000). Conclusions The clinical characteristics of patients with HBV/HCV coinfection were significantly different among different HCV contamination mode. PTCH patients have the characteristics of older age, more cirrhosis and mild degree of liver injury; IDU patients have the characteristics of yonger age, fewer cirrhosis and severe liver injury.
