Detection of hepatitis C core antigen in intravenous drug addictions

VernacularTitle:丙型肝炎病毒核心抗原在静脉吸毒者血清中的检测
Author: Hong CAO ¹ ; Ka ZHANG ; Xin SHU ; Qi-Huan XU ; Gang LI
Author Information

1. 中山大学附属第三医院
Keywords: Hepacivirus; Hepatitis C core antigens; Substance abuse,intravenous
From: Chinese Journal of Experimental and Clinical Virology 2011;25(4):304-306
CountryChina
Language:Chinese
Abstract: Objective To study the status of detection of hepatitis C core antigen in intravenous drug addictions, and discuss the foreground of the hepatitis C core antigen ELISA test system. Methods HCV core antigen, HCV RNA quantity, anti HCV-IgG, HBsAg were analysis in all the plasma samples taken from 93 cases of intravenous drug users. Results The specialty and sensitivity of HCV core antigen in intravenous drug addictions 100％-54％ separately. When HBsAg were positive, the sensitivity of HCV core antigen was 38％ , while HBsAg negative, the sensitivity of HCV core antigen was 69％ ( P ＜ 0. 01 ).Conclusion The detections of HCV core antigen showed high specialty but low sensitivity in intravenous drug addictions. The positive rate has positive relation with HCV RNA virus logarithm quantity. Coinfection with HBV are the interfere factor of HCV core antigen detection. In screening experimentations, the detection of HCV core antigen in plasma may be applied as supplement method for anti-HCV-IgG. It can also be used to monitor viremia in HCV infection.