Alterations of NK cell frequency and function in HIV/HCV co-infected patients
10.3760/cma.j.issn.1003-9279.2011.04.003
- VernacularTitle:HIV/HCV共感染者NK细胞数量和功能的研究
- Author:
Xin ZHANG
1
;
Peng ZHAO
;
Fu-Biao KANG
;
Xin-Wei ZHANG
;
Chan SI
;
Xue-Li CHEN
;
Wei-Wei CHEN
;
Min ZHAO
Author Information
1. 解放军第三零二医院
- Keywords:
HIV;
Hepatitis viruses;
Infections;
Killer cells,natural
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(4):248-250
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the impacts of HIV/HCV co-infection to NK cells by investigating the changes of frequencies and functions of NK cells in HIV/HCV co-infected patients. Methods Frequencies and counts of NK cells were measured in patients with HIV mono-infection, HCV monoinfection, HIV/HCV co-infection and health control (HC) group by flow cytometer ( FCM ). After stimulated with PMA and K562 cells, PBMCs were examined the proportion of IFN-γ+ NK cells by FCM. Proportion of killed K562 cells were detected to analyze the killing functions of NK cells. Results The frequencies of NK cells, the percentages of IFN-γ+ NK cells as well as the functions of NK cells killing the K562 cells in HIV/ HCV co-infection, HIV mono-infection and HCV mono-infection groups were all lower than those of HC group significantly, the absolute counts and killing functions of NK cells in co-infection group were significantly lower than those of HIV or HCV mono-infection group. Conclusions The counts and functions of NK cells were affected more in HIV/HCV co-infections than those in HIV or HCV mono-infection.
