To investigate the relationship of alcohol intake and hepatocellular carcinoma among patients with hepatitis B virus infection
10.3760/cma.j.issn.1003-9279.2011.05.004
- VernacularTitle:饮酒在HBV相关性肝细胞癌发生中的作用
- Author:
Gui-Ting ZHU
1
;
Guo-Qiang LOU
;
Jun-Ping SHI
Author Information
1. 杭州师范大学附属医院
- Keywords:
Alcohol;
Hepatitis B;
chronic;
Carcinoma;
hepatocellular
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(5):328-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of alcohol intake and hepatocellular carcinoma among patients with hepatitis B virus infection.Methods A total of 553 patients with HCC and 160 control subjects affected with hepatitis B virus were recruited.Serum virology,serum biochemistry,as well as demographic information were studied.Finally,risk factors were selected by stepwise Logistic regression analyse.Odds ratios (ORs) were estimated for each risk factor.According to alcohol intake,HCC patients were divided into three groups,then to observe the differences between them.Results Elevated AST,GGT,ALP and AFP levels were seen more frequently in the HCC case groups compared to control group (P ＜ 0.05 ).Multivariate analysis revealed that heavy alcohol use,smoking,positive family history of liver cancer is associated with HCC development among patients with hepatitis B virus infection.Significantly increased risk was found among patients for heavy alcohol use [A =2.66(2.01-3.50) ] and for smoking [A =2.51(1.66-3.80) ] and for positive family history of liver cancer [A =1.64( 1.04-2.59) ].Compared to patients who did not have alcohol use,elevated GGT and ALP were seen more frequently in patients who had alcohol use either mild or heavy ( P ＜ 0.05 ).Conclusions Heavy alcohol use,smoking,positive family history of liver cancer is positive correlation with HCC development among patients with hepatitis B virus infection in China.In patients with hepatitis B virus infection who also has history of heavy alcohol,the most risk factor of HCC is hepatitis B virus infection,not alcohol.
