Relationship between intrauterine infection and the gene polymorphism of DC-SIGN/DC-SIGNR in the pregnant women of HBV positive
10.3760/cma.j.issn.1003-9279.2011.05.005
- VernacularTitle:HBV阳性孕妇DC-SIGN/DC-SIGNR基因多态性与宫内感染关系的研究
- Author:
Shou-Rong LIU
1
;
Hui-Bing WENG
;
Jing WU
;
Zhong-Dong ZHANG
;
Yan-Mei ZENG
;
Hong-Fei TIAN
Author Information
1. 杭州市第六人民医院
- Keywords:
Hepatitis B virus;
Disease transmission,vertical;
Genes;
Polymorphism (genetics)
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(5):331-333
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of the individual genotype differences of DC-SIGN and DC-SIGNR on the mother-to-neonate intrauterine infection of HBV.Methods The genotypes of the gene DC-SIGN and DC-SIGNR in the pregnant women with HBV positive were detected by PCR and agarose gel electrophoresis.The significant difference of gene diversity of DC-SIGN and DC-SIGNR was analyzed by chi-square test.Results ①All of 29 cases in intrauterine infection group were 7/7 DC-SIGN genotype.In the non-intrauterine infection group,7/5 genotype were observed in 2 of 54 cases,and the other 52 cases were 7/7 genotype.The two groups was no significant difference ( P =0.54 ).②29 cases of intrauterine infection group was observed 4 genotypes of DC-SIGNR such as 7/7,7/5,9/7 and 6/5,the genotype frequencies were 0.3793,0.3448,0.2414 and 0.0345 respectively.54 cases of non-intrauterine infection group was found 6 genotypes such as 7/7,7/5,9/5,9/7,7/6 and 6/5,genotype frequencies were 0.5186,0.1481,0.0926,0.1852,0.0370 and 0.0185 respectively.The distribution of 7/5 genotype in the intrauterine infection group (29 cases) and the non-intrauterine infection group (54 cases ) was statistically significant ( P =0.038 ),and no significant difference was found in other genotypes between the two groups (P ＞ 0.05 ).Conclusion The gene DC-SIGN showed relatively little variation in the pregnant women infected with HBV.On the countrary,there were multiple genotypes of the gene DC-SIGNR in these women,and the genotype “7/5” of DC-SIGNR might be one of the susceptibility genes associated with intrauterine infection.
