The mutation patterns of HBV P gene and genotyping in patients with lanivudine-resistant chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2011.05.008
- VernacularTitle:拉米夫定耐药慢性乙型肝炎患者HBV P区基因突变模式与基因型的关系
- Author:
Jia-Liang TANG
1
;
Jian-Kang ZHOU
Author Information
1. 绍兴市斗门人民医院
- Keywords:
Hepatitis B,chronic;
Lamivudine;
Drug resistance;
viral;
Mutation;
Genotype
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(5):342-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the mutation patters of HBV P gene and genotyping of heptitis B virus in patients with chronic hepatitis B ( CHB ) after the emergence of drug-resistance during lamivudine (LAM) therapy.Methods LAM-resistant mutations and genotype of HBV were dectected in patients with LAM-resistant CHB in our hospital from Sep.2008 to June.2010.Result 107 patients had 8 mutation patterns.YMDD mutations happened in 100％,only YMDDmutation were 43 patients,while others were YMDD combined with rtL180M mutations; the HBV genotype among 107chronic hepatitis was mainly B (25.2％) and C (73.8％) and only 1 patient was happend B and C mixed infection.Genetype C was mainly YMDD combined with rtL180M mutations pattern,the rate is 60.7％ (48/79) ;while genetype B was mainly rtM204 mutation pattern,the rate is 66.7％ (18/27);there were significant difference between the genetype B and C in mutation pattern(x2=8.4,7.2,respectively,P ＜0.01 ).Conclusion YMDD mutation is the major mutation pattern of HBV P gene after emergence of LAM-resistance.Genotypes of hepatitis B virus can determine the related mulation patterns of HBV P gene.
