A survey of levels of antibodies against influenza viruses in the population of Wuxi City
10.3760/cma.j.issn.1003-9279.2011.05.011
- VernacularTitle:无锡市流感病毒抗体水平调查
- Author:
Feng-Xing YOU
1
;
Na SUN
;
Guang-Yuan MA
;
Miao-Miao WANG
;
Dan SA
;
Chao SHI
;
Jia-Lin WU
;
Xia LIN
;
Yong XIAO
;
Yan-Hua QIAN
;
Yong JIANG
;
Jie XIE
;
Ya-Yong JI
;
Hong-Xia GUAN
Author Information
1. 无锡市疾病预防控制中心
- Keywords:
Influenza A virus;
Neutralization tests
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(5):351-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate levels of antibodies against type A and type C influenza viruses and those against the 2009 H1N1 influenza A virus (before and after the 2009 H1N1 pandemic )among residents in Wuxi.To compare levels of antibodies against the 2009 H1N1 influenza virus (one year after the pandemic) in the unvaccinated population with those in the population who received vaccine.Methods Serum samples were collected from subjects (aged 1-60 years) during September 2008 to May 2009,and during September 2010 to January 2011.Also collected were serum samples from adults who had received vaccines for pandemic (H1N1) 2009 for one year.Antibody response to influenza viruses was measured using hemagglutination inhibition (HI) assay.Seropositivity rate,seroprotection rate and geometric mean titer (GMT) were compared for each age group during different periods.Results Before the outbreak of the 2009 H1N1 pandemic,seropositivity rate,seroprotection rate and GMT among the study subjects in were 2.86％ (4/140),0.71％ (1/140) and 5.23,respectively.One year after the outbreak,seropositivity rate,seroprotection rate and GMT among the study subjects were 66.33％,37.76％ and 19.17,respectively.Among them,adult subjects showed 50.00％ seropositivity rate,19.44％seroprotection rate and 13.09 GMT,while adult subjects who had received vaccine for one year showed 61.36％ seropositivity rate,22.73％ seroprotection rate and 14.14 GMT.No significant difference was observed between these two populations (P ＞ 0.05 for all three indexes).Furthermore,before the outbreak of the 2009 H1N1 pandemic,levels of antibodies against seasonal influenza viruses among the study subjects were as follows:for H1N1 virus,seropositivity rate,seroprotection rate and GMT were 55.00％,35.00％and 16.90,respectively; for H3N2 virus,seropositivity rate,seroprotection rate and GMT were 86.40％,84.30％ and 58.56,respectively.Conclusion One year after the 2009 H1N1 influenza A virus had spread to Wuxi,the population levels of antibodies against this virus have approached those against seasonal influenza viruses,as reflected by seropositivity rates,seroproection rates and GMT.Moreover,considerable levels of antibodies against seasonal influenza viruses were observed in populations,indicating no seasonal influenza outbreak would occur recently.
