Expression of MT1-MMP and RECK protein in human gastric carcinoma
10.3760/cma.j.issn.1003-9279.2011.05.015
- VernacularTitle:胃癌MT1-MMP、RECK蛋白的表达及其意义
- Author:
Bo SHEN
1
;
Ma-Qing ZHENG
;
Xin-Yu XU
;
Fu-Gen MO
;
Tong ZHANG
;
Ji-Feng FENG
Author Information
1. 江苏省肿瘤医院
- Keywords:
Matrix metalloproteinases;
Cysteine proteinase inhibitors;
Gastrointestinal neoplasms;
Immunohistochemistry
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(5):364-367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of membrane-type-1 matrix metalloproteinase (MT1-MMP) and reversion-inducing cysteine-rich protein with Kazal motifs (RECK) in gastric carcinoma,and investigate its clinical significance,at the same time analyze the correlation between MT1-MMP and RECK expression.Methods MT1-MMP and RECK expression in surgically resected tissue samples of gastric carcinoma was examined by immunohistochemical method (two-step method),and its correlation with clinicopathological factors was analyzed.Results Among the 44 gastric carcinoma samples,37 (84.1％ )were stained positive for MT1-MMP,and 31(70.5％ ) for RECK.The expression of MT1-MMP was much higher in poorly differentiated gastric carcinoma samples than moderately and well-differentiated samples (P =0.015).The expression level of MT1-MMP was associated with invasive depth of tumor cells (P =0.007),but no difference between sex and lymph node metastasis.On the contrary,the well-differentiated samples showed higher expression of RECK than poorly and moderately differentiated gastric carcinoma samples (P =0.006).The expression level of RECK did not correlate with sex,lymph node metastasis and invasive depth of tumor cells.RECK expression showed no relation to MT1-MMP expression in the gastric carcinoma.Conclusion Overexpression of MT1-MMP in gastric carcinoma may play an important role during tumor differentiation and metastasis,the RECK protein may have positive effects on the tumor differentiation.
