Analysis of the test results of HBV serum markers and HBV DNA of the neonates born to HBsAg-positive mothers
10.3760/cma.j.issn.1003-9279.2011.06.013
- VernacularTitle:HBsAg阳性产妇所生新生儿的HBV血清标志物及HBV DNA的检测结果分析
- Author:
Miao-Chan WANG
1
;
Ai-Fang XU
;
Yong-Le ZHANG
;
Dong-Ming XU
Author Information
1. 杭州第六人民医院
- Keywords:
Hepatitis B virus;
Infant,newborn;
Biological markers
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(6):445-447
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the HBV serum markers and HBV DNA expressions of the neonates born to the HBsAg-positive mothers.Methods By detecting serum immunity markers of hepatitis B virus (5 items) and serum HBV DNA of 283 neonates (a pair of twins) born to 282 HBsAg-positive mothers.Results 12 patterns emerge from the study of the hepatitis B serum markers of 283 neonates.Topping the list is the combination of HBeAg and anti-HBc positive accounting for 48.41％ (137/283),followed by the combination of anti-Hbe and anti-HBc positive accounting for 22.26％ ( 62/283 ).The third highest combination is that of HBsAg,HBeAg and anti-HBc positive accounting for 12.37％ (35/283).There are five combinations accounting for 16.61％ (47/283),each with HBsAg-positive.No case is found of the five items all negative or only HBsAb positive.Five cases are detected of serum HBV DNA ≥ 1 ×103IU/ml accounting for 1.77％.Conclusions Neonates born to HBsAg-positive mothers display complex patterns of serum hepatitis B markers,the dominant pattern being the combination of HBeAg and anti-HBc positive.Cases of serum HBV DNA ≥ 1 × 103IU/ml are rare.
