The clinical efficacy and safety of adefovir dipivoxil in combination with bicyclol for the treatment of senior patients with chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2011.06.016
- VernacularTitle:阿德福韦酯联合双环醇治疗老年慢性乙型肝炎的疗效及安全性分析
- Author:
Wen-Jin ZHANG
1
;
Shao-Ping CAI
;
Zhen-Ping FAN
;
Ying-Jie JI
;
Wei-Ping HE
Author Information
1. 解放军第302医院
- Keywords:
Health services for the aged;
Hepatitis B,chronic;
Bicyclol;
Adefovir dipivoxil
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(6):453-456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of adefovir dipivoxil (ADV) in combination with bicyclol for the treatment of chronic hepatitis B ( CHB ) in seniors.Methods 96 senior patients with CHB were randomly divided into two groups,the treatment group and the control group.On the basis of routine liver protective treatment,patients in the treatment group received ADV (10 mg/d ) and bicyclol tablets( 25mg,tid.)orally,and those in the control group were orally administrated ADV tablets (10 mg/d) only.The treatment course for both groups was 24 weeks. Serum ALT,AST,and alterations of virological parameters were observed before and after the treatment.Results Before and at the end of the 24 weeks treatment,ALT level for the treatment group was (208.44 ± 94.22) and (34.47 ± 12.79) U/L,and those for the control group was ( 205.73 ± 96.48 ) and (44.20 ± 21.96 ) U/L,respectively ( difference between groups P ＜0.01 ).At the end of the 24 weeks treatment,ALT normalization rates for the treatment group and the control group were 76.6％ and 54.5％,respectively,and AST normalization rates for them were 76.6％ and 54.5％,respectively (both differences between groups P ＜ 0.05 ) ; HBV DNA loads for the treatment group and the control group were decreased by (3.1 ± 1.40) lgIU/ml and (2.98 ± 1.17) lgIU/ ml,respectively ( difference between groups P ＞ 0.05 ).The incidence rates of adverse events between two groups were not statistically significant.Conclusion It suggested that the treatment of ADV in combination with bicyclol for senior patients with CHB is effective and safe.
