Clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation
10.3760/cma.j.issn.1003-9279.2011.06.018
- VernacularTitle:家族聚集性HBV相关慢加急性肝衰竭患者临床特点分析
- Author:
Bing ZHU
1
;
Yi-Hui RONG
;
Hong-Ling LIU
;
Ai-Min ZHANG
;
Hong ZANG
;
Long XIAO
;
Shao-Li YOU
;
Shao-Jie XIN
Author Information
1. 解放军第302医院
- Keywords:
Liver failure;
Biasc(epidemiology);
clinical medicine
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(6):460-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical characteristics of hepatitis B virus-related acute-on-chronic liver failure patients with familial aggregation.Methods 275 patients with hepatitis B virus - related acute-on-chronic liver failure were investigated.The patients were divided into familial aggregation and nonfamilial aggregation group basis on their epidemiological features.Clinical data and biochemical indicators between the two groups were analyzed statistically.Results 93 of 275 patients( 33.82％ ) case were family aggregation.There was no significant difference compared with chronic hepatitis B patients( 38.3％ ).The mean age of the two groups was 45.98 and 43.61 years old,respectively (P ＞ 0.05 ).The rates of liver cirrhosis in family aggregation group were significant higher than non - familial aggregation group( 73.91％ vs 58.24％,p ＜ 0.05 ).Serum total (TBil) and prothrombin activities ( PTA ) were no significant difference between the two groups,but ALT level in familial aggregation group was much higher (407.80U/L vs 256.45 U/L,P0.05 ).Conclusion Familial aggregation were not related to acute-on-chronic liver failure in chronic HBV hepatitis patients. But the rate of liver cirrhosis were higher in patients with familial aggregation.
