Expression of fibroblast activation protein in HBV related hepatocellular carcinoma.
- Author:
Ye-Qiong ZHANG
1
;
Jian-Xi LU
;
Hai-Xia SUN
;
Xin SHU
;
Hong CAO
;
Xing-Fei PAN
;
Qi-Huan XU
;
Gang LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Hepatocellular; etiology; metabolism; Female; Gelatinases; genetics; physiology; Gene Expression Regulation, Neoplastic; Hepatitis B; complications; Humans; Liver Neoplasms; etiology; metabolism; Male; Membrane Proteins; genetics; physiology; Middle Aged; RNA, Messenger; analysis; Serine Endopeptidases; genetics; physiology
- From: Chinese Journal of Experimental and Clinical Virology 2011;25(6):463-465
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the gene expression level of fibroblast activation protein in HBV related hepatocellular carcinoma patients and discuss its clinical significance.
METHODSFAP gene expression in 33 hepatocellular carcinoma patients cancer tissues, peficancerous tissues, distant relative normal liver tissues and 13 normal liver tissues were examined by reverse transcription PCR; and real-time fluorescent quantitative PCR (qRT-PCR) was used to quantify their expression.
RESULTSFAP were expressed in all the tissues,the relative expression values in cancer tissues, peficancerous tissues and distant relative normal liver tissues were 5.14 +/- 6.69, 1.58 +/- 0.96, 1.63 +/- 0.94, respectively, the differences were statistically significant (F = 4.401, P < 0.05); and in TNM stage I, II, IIII, they were 2.89 +/- 3.35, 4.15 +/- 4.69, 10.09 +/- 9.51 respectively; in well-differentiated, differentiated and poorly differentiated hepatocellular carcinoma were 1.62 +/- 1.74, 3.84 +/- 3.79, 1.26 +/- 13.34 respectively. The differences were all statistically significant (P < 0.05).
CONCLUSIONFAP may play an important role in the occurrence and development of HBV related hepatocellular carcinoma.
