Expression of fibroblast activation protein in HBV related hepatocellular carcinoma
10.3760/cma.j.issn.1003-9279.2011.06.019
- VernacularTitle:成纤维细胞激活蛋白在乙肝相关性肝癌中的表达及其临床意义
- Author:
Ye-Qiong ZHANG
1
;
Jian-Xi LU
;
Hai-Xia SUN
;
Xin SHU
;
Hong CAO
;
Xing-Fei PAN
;
Qi-Huan XU
;
Gang LI
Author Information
1. 中山大学附属第三医院
- Keywords:
Carcinoma,hepatocellular;
Hepatitis B virus;
Fibroblast growth factors;
Hepatocytes
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(6):463-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the gene expression level of fibroblast activation protein in HBV related hepatocellular carcinoma patients and discuss its clinical significance.Methods FAP gene expression in 33 hepatocellular carcinoma patients cancer tissues,peficancerous tissues,distant relative normal liver tissues and 13 normal liver tissues were examined by reverse transcription PCR;and real-time fluorescent quantitative PCR (qRT-PCR) was used to quantify their expression.Results FAP were expressed in all the tissues,the relative expression values in cancer tissues,peficancerous tissues and distant relative normal liver tissues were 5.14 ± 6.69,1.58 ± 0.96,1.63 ± 0.94,respectively,the differences were statistically significant ( F =4.401,P < 0.05 ) ; and in TN M stage Ⅰ,Ⅱ,Ⅲ,they were 2.89 ± 3.35,4.15 ±4.69,10.09 ± 9.51 respectively; in well - differentiated,differentiated and poorly differentiated hepatocellular carcinoma were 1.62 ± 1.74,3.84 ±3.79,11.26 ± 13.34respectively.The differences were all statistically significant( P < 0.05 ).Conclusion FAP may play an important role in the occurrence and development of HBV related hepatocellular carcinoma.