Clinical significance and detection of the expression of CD25 - CD127 - on CD4 + T cells in peripheral blood in patients with hepatitis B
10.3760/cma.j.issn.1003-9279.2011.06.022
- VernacularTitle:乙型肝炎病毒感染者外周血CD4+T细胞CD25- CD127-表达的检测及临床意义
- Author:
Jun YE
1
;
Ya-Bao CHEN
;
Hong-Tao XU
;
Jian-Chun XIAN
;
Li-Xing ZHANG
;
Mei LIN
;
Jun-Xing HUANG
Author Information
1. 江苏省泰州市人民医院
- Keywords:
Hepatitis B virus;
T-lymphocyes;
Receptors,interleukin-2;
Receptors,interleukin-7;
Flow cytometry
- From:
Chinese Journal of Experimental and Clinical Virology
2011;25(6):474-476
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance and detection of the expression of CD25 - CD127 - on CD4 + T cells in peripheral blood in patients with hepatitis B.Methods The expression of CD25- CD127- on CD4 + T cells were measured by using flow cytometry in 53 patients with chronic hepatitis B,53 carrier with hepatitis B virus and 26 healthy blood donors,and follow up 20 patients with HBV-DNA positive treated with interferon.Results ① Compared with healthy controls,the expression of CD25 - CD127 - on CD4 + T cells in patients and carrier with hepatitis B virus were lower( Q =4.559,P ＜0.05 ; Q =6.230,P ＜ 0.05 ).②The expression of CD25 - CD127 - on CD4 + T cells in patients with HBV-DNA positive( n =77 ) was lower than that of negative ( n =29 ) ( t =2.290,P =0.024 ).③Compared with the prior treatment,the expression of CD25 - CD127 - on CD4 + T cells in patients with B hepatitis were lower after interferon treated with 12 weeks(t =2.469,P =0.024).Conclusion It suggested that the CD25-CD127- expression on CD4 + T cells correlated with viral infections and cleared,exogenous interferon could decrease CD25 - CD127 - expression on CD4 + T cells.
