Efficacy of peg interferon alpha-2a in combination with ribavirin in treatment of with hepatitis C cirrhosis patients.
- Author:
Guang-Wei LIU
1
;
Chun-Fang WANG
;
Wen-Xia ZHAO
;
Su-Ping MA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Drug Therapy, Combination; Female; Hepatitis C, Chronic; drug therapy; virology; Humans; Interferon-alpha; administration & dosage; adverse effects; Liver Cirrhosis; drug therapy; virology; Male; Middle Aged; Polyethylene Glycols; administration & dosage; adverse effects; Recombinant Proteins; administration & dosage; adverse effects; Ribavirin; administration & dosage; adverse effects
- From: Chinese Journal of Experimental and Clinical Virology 2011;25(6):477-479
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical efficacy of PEG Interferon alpha-2a combined with ribavirin in treatment of with hepatitis C cirrhosis patients.
METHODS21 patients with chronic hepatitis C cirrhosis (treated group) ,were treated with peg-IFNalpha-2a 135 -180 microg subcutaneously, 1 week,ribavirin tablets 800 -1000 mg/d,48 weeks of treatment and follow-up 24 weeks, 20 patients with Chronic hepatitis C (control group), were treated with peg-IFNalpha-2a 135 -180 microg subcutaneously, 1 week,ribavirin tablets 600 -1000 mg/d, 48 weeks of treatment, follow-up 24 weeks, comparison of rapid virological response (RVR) rates, early virologic response (EVR) rate, sustained virologic response (SVR) rate, adverse reactions was observed.
RESULTSThe differences of RVR, EVR, ETVR in two groups is not significant, but SVR in treatment group was lower (P < 0.05), and has a higher incidence bone marrow suppression and anemia (P < 0.05). Flu-like symptoms, hair loss, gastrointestinal reactions and other adverse reactions was no significant difference between the two groups.
CONCLUSIONThe use of 135 microg peg-IFNalpha-2a and individual in low-dose ribavirin hepatitis C patients with cirrhosis is more security,could get a good early response, but sustained virologic response (SVR) rates is lower than hepatitis C patients. Blood, liver and kidney function should be closely observed during treatment process.
