Investigation of the relationship between apolipoprotein gene polymorphism and hepatitis B virus infection in China.
- Author:
Zhi-Nong YIN
1
;
Xin ZHOU
;
Shen-Kai YAN
;
Jun-Wen WANG
;
Qing-Ling MENG
;
Wei LIU
Author Information
- Publication Type:Journal Article
- MeSH: Apolipoprotein A-I; genetics; Apolipoprotein C-III; genetics; Apolipoproteins; genetics; Apolipoproteins B; genetics; China; Genotype; Hepatitis B; genetics; Humans; Polymorphism, Genetic
- From: Chinese Journal of Experimental and Clinical Virology 2012;26(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the gene polymorphisms of ApoAI-75 Msp1, ApoB Msp1, ApoCIII Sst1, LRP5, and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers.
METHODSThe patients are divided into 9 groups. There were a total of 720 cases, 80 patients in each group, The patients was carried out by SnaPshot method (single-base multilocus micro-sequencing), and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results.
RESULTSThere was association between gene polymorphisms of ApoAI-75Msp1 and ApoE and different modes of two pairs of semi-hepatitis B (P < 0.05), while there wasn't any association between gene polymorphisms of ApoB-Msp1, ApoCIII-Sst1, LRP5 and different modes of two pairs of semi-hepatitis B (P > 0.05).
CONCLUSIONThe gene polymorphism of ApoAI-75Msp1 and ApoE was associated with the different modes of HBV markers.
