Investigation of the relationship between apolipoprotein gene polymorphism and hepatitis B virus infection in China

VernacularTitle:乙型肝炎与载脂蛋白基因多态性相关性研究
Author: Zhi-Nong YIN ¹ ; Xin ZHOU ; Shen-Kai YAN ; Jun-Wen WANG ; Qing-Ling MENG ; Wei LIU
Author Information

1. 北京市垂杨柳医院,暨北京微创医院
Keywords: Carrier proteins; Genes; Polymorphism (genetics); Hepatitis B
From: Chinese Journal of Experimental and Clinical Virology 2012;26(1):28-30
CountryChina
Language:Chinese
Abstract: Objective To explore the gene polymorphisms of ApoAⅠ-75 Msp1,ApoB Msp1,ApoCⅢSst1,LRP5,and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers.Methods The patients are divided into 9 groups.There were a total of 720 cases,80 patients in each group,The patients was carried out by SnaPshot method (single-base multilocus micro-sequencing),and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results. Results There was association between gene polymorphisms of ApoAⅠ-75Msp1 and ApoE and different modes of two pairs of semi-hepatitis B ( P ＜ 0.05 ),while there wasn't any association between gene polymorphisms of ApoB-Msp1,ApoCⅢ-Sst1, LRP5 and different modes of two pairs of semi-hepatitis B (P ＞ 0.05 ).Conclusion The gene polymorphism of ApoAⅠ-75Msp1 and ApoE was associated with the different modes of HBV markers.