The relationship of HBeAg status with HBV DNA loads, MELD scores in patients with acute-onchronic hepatitis B liver failure during terminal phases
10.3760/cma.j.issn.1003-9279.2012.01.018
- VernacularTitle:乙肝加急性肝衰竭患者HBeAg与HBV DNA载量和终末期肝病模型分值关系的分析
- Author:
Jing LAI
1
;
Xue-Jun LI
;
Shao-Quan ZHANG
;
Qi-Huan XU
;
Jian-Yun ZHU
;
Wei-Min KE
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis Be antigens;
Liver failure;
Viral load;
Model for end-stage liver disease
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(1):51-53
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship and clinical significances of HBeAg status with serum HBV DNA loads,model for end-stage liver disease (MELD) scores in patients with acute-on-chronic hepatitis B liver failure during terminal phase.Methods 120 fatal patients were enrolled.At three phases of 0 -14 d,15 -28 d and 29 -90 d before death,they were detected serum HBeAg,HBV DNA loads order meanwhile MELD scores were calculated.Results In 51 patients with HBeAg positive,HBV DNA levels were (5.25 ± 1.99),(5.45 ± 1.47) and (6.06 ± 1.77) log10 copies/ml while MELD scores were (30.33 ± 5.25 ),(26.36 ± 6.43 ) and (20.13 ± 6.47) respectively.In 69 patients with HBeAg negative,HBV DNA loads were (5.14 ± 1.84),(5.49 ± 1.75 ) and (4.62 ± 1.65 ) log10 copies/ml while MELD scores were 32.38 ± 9.95,28.17 ±6.82 and 26.19 ± 5.56 in sequence.Compared with the same phase between HBeAg-positive group and HBeAg-negative group,significant differences in both HBV DNA loads and MELD scores were found only at the phase of 29 - 90 d (P ＜ 0.05 ).In multiple comparisons among three phases,regardless of the HBeAg status,there wasn't significant difference for HBV DNA loads (P ＞0.05).But increasing MELD scores are associated with the disease exacerbation and significant differences were found (P ＜ 0.05).Conclusions To initiate acute-on-chronic hepatitis B liver failure,serum HBV DNA loads of HBeAg-positive patients are higher than that of HBeAg-negative ones.Once ACLF has been initiated,sustained high HBV DNA loads may promote the disease worsened and be fatal regardless of the HBeAg status.
