Relationship between mannose-binding protein gene polymorphisms and disease progression and HBV DNA in patients with chronic HBV infection
10.3760/cma.j.issn.1003-9279.2012.02.004
- VernacularTitle:慢性HBV感染者甘露糖结合蛋白基因多态性与疾病进展及与HBV DNA相关性的研究
- Author:
Rui-Dan ZHENG
1
;
Jian-Neng CHEN
;
Jian-Ping GAO
;
Qun-Ying ZHUANG
;
Qing-Chuan ZHU
;
Yan-Hui LU
;
Zhen-Qun LIN
;
Wu-Hua HONG
;
Qing-Duan LI
;
CHEN-Zhe
Author Information
1. 厦门大学附属东南医院
- Keywords:
Manannose;
Hepatitis B,chronce;
DNA;
Genes
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(2):90-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the influences of Mannose binding protein (MBP) gene polymorphisms on HBV DNA loads and on the progression of liver disease in patients with chronic HBV infeclion.Method The Codons on 54 MBP gene polymorphisms and HBV DNA loads in a cohort of 395 patients with chronic HBV infection,including 244 with chronic hepatitis B (CHB),151 with liver cirrhosis(LC) and 88 normal controls were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and fluorescent quantitative PCR (FQ-PCR).Result The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC in CHB group showed no significant differences comparing to the normal control group ( P ＞ 0.05 ).The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC on CHB group (severe),compensation phase of LC group and decompensation phase of LC group were higher than those in the normal control group (P ＜ 0.05 ),the genetic polymorphism of decompensation of LC was 36.5 ％,highest of all.The MBP genotype frequencies of GGC/GAC and alleles genetic frequencies of GAC of patients with chronic HBV infection were not changed with the differences of HBV-DNA loads.Conclusion The codes on 54 MBP gene polymorphisms is not closely related to HBV DNA loads,but was associated with the progression of hepatitis B infection.
