Structural components of Chinese medicine and pharmacology network: systematical overall regulation on pathological network.
- Author:
Juan CHEN
;
Jun-fei GU
;
Chun-fei WANG
;
Jia-rui YUAN
;
Bing-jie ZHAO
;
Li ZHANG
;
Xu-dong CHENG
;
Lang FENG
;
Xiao-bin JIA
- Publication Type:Journal Article
- MeSH:
Drug Interactions;
Drug Therapy;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Gene Regulatory Networks;
drug effects;
Humans;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2015;40(4):758-764
- CountryChina
- Language:Chinese
-
Abstract:
Development of the disease is the result of several factors involved in biological network changes. The nature of drug intervention is to regulate these pathological changes to the normal range. Advantages of traditional Chinese medicine (TCM) are to integrally and systematically regulate this biological networks and systematic pathology through multi-targets, multi-levels, multi-channels. Structural components TCM provides the controlled and precise basis "substance" for this regulation and also to clarify the "truth" of the nature of the regulation by the network pharmacology. Network pharmacology provides new strategy for the research on mechanism of structural components TCM. This study not only reflects the overall characteristics of the development of the disease, but also fully embodies the essence of TCM for preventing and treating diseases through changing traditional model on "one drug, one gene, one disease". This paper explores systematically the integration essence, features and research strategies of structural components TCM and the network pharmacology, understand the interaction of structural components TCM and body from the perspective of the overall concept of improving or restoring the balance of.biological networks. It is effective measure to reveal the structure of a multi-component for regulating biological networks mechanisms, and also provide new ideas and methods for further scientific research and innovation of structural component TCM.
