Studies on preparation by SPG membrane emulsification method and in vitro characterization of tetradrine-tashionone II(A)-PLGA composite microspheres.
- Author:
Jin LU
;
Meng ZHANG
;
Hua-xu ZHU
;
Li-wei GUO
;
Lin-mei PAN
;
Ting-ming FU
- Publication Type:Journal Article
- MeSH:
Benzofurans;
chemistry;
Benzylisoquinolines;
chemistry;
Drug Carriers;
chemistry;
Drug Compounding;
instrumentation;
methods;
Drugs, Chinese Herbal;
chemistry;
Kinetics;
Lactic Acid;
chemistry;
Microspheres;
Particle Size;
Polyglycolic Acid;
chemistry
- From:
China Journal of Chinese Materia Medica
2015;40(6):1091-1096
- CountryChina
- Language:Chinese
-
Abstract:
Tetradrine-tashionone II(A)-PLGA composite microspheres were prepared by the SPG membrane emulsification method, and the characterization of tetradrine-tashionone II(A) -PLGA composite microspheres were studied in this experiment. The results of IR, DSC and XRD showed that teradrine and tashionone II(A) in composite microspheres were highly dispersed in the PLGA with amorphous form. The results of tetradrine-tashionone II(A) -PLGA composite microspheres in vitro release experiment showed that the cumulative release amounts of tetradrine and tashionone II(A) were 6.44% and 3.60% in 24 h, and the cumulative release amounts of tetradrine and tashionone II(A) were 89.02% and 21.24% in 17 d. The process of drug in vitro release accorded with the model of Riger-Peppas. Tetradrine-tashionone II(A) -PLGA composite microspheres had slow-release effect, and it could significantly reduce the burst release, prolong the therapeutic time, decrease the dosage of drugs and provide a new idea and method to prepare traditional Chinese medicine compound.
