Chemical constituents from culture of Streptomyces sp. CPCC 202950.
- Author:
Ming-hua CHEN
;
Ye-xiang WU
;
Biao DONG
;
Xiu-yong FAN
;
Li-yan YU
;
Wei JIANG
;
Shu-yi SI
- Publication Type:Journal Article
- MeSH:
Culture Media;
chemistry;
metabolism;
HIV Protease;
analysis;
HIV Protease Inhibitors;
chemistry;
isolation & purification;
Molecular Structure;
Spectrometry, Mass, Electrospray Ionization;
Streptomyces;
chemistry;
metabolism
- From:
China Journal of Chinese Materia Medica
2015;40(7):1320-1324
- CountryChina
- Language:Chinese
-
Abstract:
Eleven compounds were isolated from the culture of Streptomyces sp. CPCC 202950 by a combination of various chromatographic techniques including column chromatography over macroporous resin HP-20, MCI, and reversed-phase HPLC. Their structures were identified as 1H-pyrrole-2-carboxamide(1),5'-deoxy-5'-methylthioinosine(2), vanillamide(3), trans-3-methylthioacrylamide(4), 1,2,3,4-Tetraydro-1H-pyrido[3,4-b]indole-3-carboxylic acid(5), cyclo(L-pro-L-tyr) (6), N-[2-(4-hydroxyphenyl)]ethylacetamide(7), benzamide (8), cyclo ('L-leucyl-trans-4-hydroxy-L-proline)(9), cyclo-(Phe-Gly) (10), and tryptophan (11). Among them, compounds 1 and 2 were new natural products. In the preliminary assays, none of the compounds exhibited obvious inhibition of HIV-1 protease activity (IC50 > 10 micromol x L(-1)).
